Coalition of Silicone Survivors
Lack of Autoantibody Expression in Children Born to Mothers with Silicone Breast Implants
COSSkids is onderdeel van Coalition of Silicone Survivors - Boulder Collorado USA
Jeremiah J. Levine M.D.
Bron: Progressive Resources for Neonatal Professionals
PEDRIATICS Vol. 97 No. 2 Frebruari 1996, pp. 243-245 a review.
Jeremiah J. Levine M.D. (1), Hun-Chi Lin PhD. (2), Merrill Rowley PhD. (3), Andrew Cook (3), Suzanne S, Teuber MD (4), and Norman T. Ilowite MD (5).
(1) The Divisions of Gastroenterology and Nutrition, Schneider Children's Hospital, Long
Island Jewish Medical Center, Hyde Park, New York.
(2) Specialty Laboratories, Santa Monica, California.
(3) Center of Molocular Biology and Medicine, Monash University, Clayton, Victoria, Australia.
(4) Devision of Rheumatology, Allergy and Clinical Immunology, University of california at
Davis, Davis, California.
(5) Devision of Rheumatology, Schneider Children's Hospital, Long Island Jewish Medical
Center, Hyde Park, New York.
Objective: We determined systematically the prevalence of autoantibodies in children born to mothers with silicone breast implants and the relationships with clinical symptoms and methods of exposure.
Methods: Autoantibody expression was determined in 80 children born to mothers with silicone implants and in 42 controls. A clinical assessment score was assigned to each patient. Antinuclear as well as antibodies to mitochondrial, smooth muscle, striational myocardial, parietal cell, reticulin tissues, or subcellular compartments were measured by indirect fluorescent assay. Antibodied to nRNP (U1-RNP/snRNP); Sm; SS-A; SS-B; Scl-70; thyroid microsome; immunoglobulin (lg)G, IgM, and IgA antibodies to cardiolipin; and antibodies to native and denatured human types I and II callogen were measured by enzyme-linked immonosorbent assay. Serum complement components C3 and C4 and IgM rheumatoid factor were measured by nephelometry.
Result: Autoantibody prevalence was not significantly different between children born to mothers with silicone imolants and controls. The precense of autoantibodies was not related to the children's clinical symptoms or to the method od exposure.
Conclusions; Determination of autoantibody production is of limited clinical utility in the evaluation of children born to mothers with silicone breast implants.
Key words; silicone - implants - children - autoantibodies - breastfeeding
Submitted on November 1, 1994 --- Accepted on May 1, 1995